Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance. Cancer Cell. 2022 Oct 10. Shi Q, Shen Q, Liu Y, Shi Y, Huang W, Wang X, Li Z, Chai Y, Wang H, Hu X, Li N, Zhang Q, Cao X. 曹雪涛,A,38.585. [ PubMed ]

m6A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration. Signal Transduct Target Ther. 2022 Jun 29. Liu Y, Song R, Zhao L, Lu Z, Li Y, Zhan X, Lu F, Yang J, Niu Y, Cao X. 曹雪涛, A, 35.126. [ PubMed ]

Airway administration of bisphosphate and dexamethasone inhibits SARS-CoV-2 variant infection by targeting alveolar macrophages. Signal Transduct Target Ther. 2022 Apr 6. Wang Z, Zhou Y, Bao L, Li D, Lv J, Wang D, Li S, Liu J, Qin C, Tong WM, Huang B. 黄波, A, 35.126. [ PubMed ]

Proteomic and phosphoproteomic profiling of COVID-19-associated lung and liver injury: a report based on rhesus macaques. Signal Transduct Target Ther. 2022 Jan 28. Liu JF, Zhou YN, Lu SY, Yang YH, Wu SF, Liu DP, Peng XZ, Yang JT. 杨俊涛, A, 35.126. [ PubMed ]

Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics study with drug exploration. Signal Transduct Target Ther. 2022 May 13. Wang M, Zhang Z, Liu J, Song M, Zhang T, Chen Y, Hu H, Yang P, Li B, Song X, Pang J, Xing Y, Cao Z, Guo W, Yang H, Wang J, Yang J, Wang C. 王辰、杨俊涛, A, 35.126. [ PubMed ]

RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancy. Signal Transduct Target Ther. 2022 Jun 13. Lu Y, Huang R, Ying J, Li X, Jiao T, Guo L, Zhou H, Wang H, Tuersuntuoheti A, Liu J, Chen Q, Wang Y, Su L, Guo C, Xu F, Wang Z, Lu Y, Li K, Liang J, Huang Z, Chen X, Yao J, Hu H, Cheng X, Wan Y, Chen X, Zhang N, Miao S, Cai J, Wang L, Liu C, Song W, Zhao H. 宋伟, A, 35.126. [ PubMed ]

Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway. Nat Cell Biol. 2022 Mar. Lv J, Liu Y, Mo S, Zhou Y, Chen F, Cheng F, Li C, Saimi D, Liu M, Zhang H, Tang K, Ma J, Wang Z, Zhu Q, Tong WM, Huang B. 黄波, A, 28.123. [ PubMed ]

METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis. Nat Cell Biol. 2022 Aug. Wei X, Huo Y, Pi J, Gao Y, Rao S, He M, Wei Q, Song P, Chen Y, Lu D, Song W, Liang J, Xu L, Wang H, Hong G, Guo Y, Si Y, Xu J, Wang X, Ma Y, Yu S, Zou D, Jin J, Wang F, Yu J. 余佳, A, 28.123. [ PubMed ]

Eosinophils protect against pulmonary hypertension through 14-HDHA and 17-HDHA. Eur Respir J. 2023 Mar 2. Shu T, Zhang J, Zhou Y, Chen Z, Li J, Tang Q, Lei W, Xing Y, Wang J, Wang C. 王辰、王婧, A, 23.144. [ PubMed ]

Potential of angiotensin II receptor blocker telmisartan in reducing mortality among hospitalized patients with COVID-19 compared with recommended drugs. Cell Discov. 2022 Sep 9. Liu D, Wu P, Gu W, Yang C, Yang X, Deng X, Xu J, Jiang J, Jiang C. 蒋澄宇, A, 19.649. [ PubMed ]

MyoD is a 3D genome structure organizer for muscle cell identity. Nat Commun. 2022 Jan 11. Wang R, Chen F, Chen Q, Wan X, Shi M, Chen AK, Ma Z, Li G, Wang M, Ying Y, Liu Q, Li H, Zhang X, Ma J, Zhong J, Chen M, Zhang MQ, Zhang Y, Chen Y, Zhu D. 张勇、陈阳, A, 17.764. [ PubMed ]

SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages. Cell Mol Immunol. 2022 Feb. Wang Z, Lv J, Yu P, Qu Y, Zhou Y, Zhou L, Zhu Q, Li S, Song J, Deng W, Gao R, Liu Y, Liu J, Tong WM, Qin C, Huang B. 黄波, A, 17.7. [ PubMed ]

Avian influenza viruses suppress innate immunity by inducing trans-transcriptional readthrough via SSU72. Cell Mol Immunol. 2022 Jun. Zhao Y, Huang F, Zou Z, Bi Y, Yang Y, Zhang C, Liu Q, Shang D, Yan Y, Ju X, Mei S, Xie P, Li X, Tian M, Tan S, Lu H, Han Z, Liu K, Zhang Y, Liang J, Liang Z, Zhang Q, Chang J, Liu WJ, Feng C, Li T, Zhang MQ, Wang X, Gao GF, Liu Y, Jin N, Jiang C. 蒋澄宇, A, 17.7. [ PubMed ]

Klf4 methylated by Prmt1 restrains the commitment of primitive endoderm. Nucleic Acids Res. 2022 Feb 28. Zuo ZY, Yang GH, Wang HY, Liu SY, Zhang YJ, Cai Y, Chen F, Dai H, Xiao Y, Cheng MB, Huang Y, Zhang Y. 黄粤, A, 17.21. [ PubMed ]

Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Sci Adv. 2022 Jan 7. Wang F, Tan P, Zhang P, Ren Y, Zhou J, Li Y, Hou S, Li S, Zhang L, Ma Y, Wang C, Tang W, Wang X, Huo Y, Hu Y, Cui T, Niu C, Wang D, Liu B, Lan Y, Yu J. 余佳, A, 16.895. [ PubMed ]

RNA-binding protein hnRNP UL1 binds κB sites to attenuate NF-κB-mediated inflammation. J Autoimmun. 2022 May. Ma Z, Zhou Y, Wang Y, Xu Y, Liu Y, Liu Y, Jiang M, Zhang X, Cao X. 曹雪涛, A, 14.511. [ PubMed ]

Nuclear translocation of RIG-I promotes cellular apoptosis. J Autoimmun. 2022 Jun. Wang C, Zhou W, Liu Y, Xu Y, Zhang X, Jiang C, Jiang M, Cao X. 曹雪涛, A, 14.511. [ PubMed ]

Oncogenic β-catenin stimulation of AKT2-CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer. Proc Natl Acad Sci U S A. 2022 Sep 27. Liu F, Gai X, Wu Y, Zhang B, Wu X, Cheng R, Tang B, Shang K, Zhao N, Deng W, Chen J, Zhang Z, Gu S, Zheng L, Zhang H. 张宏冰, A, 13.45. [ PubMed ]

Elevated BICD2 DNA methylation in blood of major depressive disorder patients and reduction of depressive-like behaviors in hippocampal Bicd2-knockdown mice. Proc Natl Acad Sci U S A. 2022 Jul 26. Xiu J, Li J, Liu Z, Wei H, Zhu C, Han R, Liu Z, Zhu W, Shen Y, Xu Q. 许琪, A, 13.45. [ PubMed ]

Comprehensive assessment of cellular senescence in the tumor microenvironment. Brief Bioinform. 2022 May 13. Wang X, Ma L, Pei X, Wang H, Tang X, Pei JF, Ding YN, Qu S, Wei ZY, Wang HY, Wang X, Wei GH, Liu DP, Chen HZ. 刘德培, A, 12.8784. [ PubMed ]

Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer. Theranostics. 2022 Jan 1. Li X, Sun Z, Peng G, Xiao Y, Guo J, Wu B, Li X, Zhou W, Li J, Li Z, Bai C, Zhao L, Han Q, Zhao RC, Wang X. 王晓月, A, 12.201. [ PubMed ]

Phosphodiesterase 4D contributes to angiotensin II-induced abdominal aortic aneurysm through smooth muscle cell apoptosis. Exp Mol Med. 2022 Aug. Gao R, Guo W, Fan T, Pang J, Hou Y, Feng X, Li B, Ge W, Fan T, Zhang T, Lu J, Jing H, Jin M, Yan C, Wang J. 王婧, A, 11.59. [ PubMed ]

Single-cell transcriptomics of mouse lung reveal inflammatory memory neutrophils in allergic asthma. Allergy. 2022 Jun. Li Z, Feng Y, Liu H, Yang H, Li J, Zhou Y, Pang J, Yang P, Zhao H, Wang J. 王婧, A, 11.45. [ PubMed ]

The role of immunoglobulin E and mast cells in hypertension. Cardiovasc Res. 2022 Nov 10. Ge W, Guo X, Song X, Pang J, Zou X, Liu Y, Niu Y, Li Z, Zhao H, Gao R, Wang J. 王婧, A, 11.45. [ PubMed ]

Nrf2 expands the intracellular pool of the chaperone AHSP in a cellular model of β-thalassemia. Redox Biol. 2022 Apr. Han G, Cao C, Yang X, Zhao GW, Hu XJ, Yu DL, Yang RF, Yang K, Zhang YY, Wang WT, Liu XZ, Xu P, Liu XH, Chen P, Xue Z, Liu DP, Lv X. 吕湘, A, 11.271. [ PubMed ]

Peptide Binder with High-Affinity for the SARS-CoV-2 Spike Receptor-Binding Domain. ACS Appl Mater Interfaces. 2022 Jun 29. Yu L, Wang R, Wen T, Liu L, Wang T, Liu S, Xu H, Wang C.王晨轩, A, 10.382. [ PubMed ]

Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis. Nat Immunol. 2022 Oct. Wang W, Xu Y, Wang L, Zhu Z, Aodeng S, Chen H, Cai M, Huang Z, Han J, Wang L, Lin Y, Hu Y, Zhou L, Wang X, Zha Y, Jiang W, Gao Z, He W, Lv W, Zhang J.何维/张建民, B1, 31.003. [ PubMed ]

Modeling Human Thyroid Development by Fetal Tissue-Derived Organoid Culture. Adv Sci (Weinh). 2022 Mar. Liang J, Qian J, Yang L, Chen X, Wang X, Lin X, Wang X, Zhao B. 王晓月, B1, 18.939. [ PubMed ]

Exploring links between 2-oxoglutarate-dependent oxygenases and Alzheimer's disease. Alzheimers Dement. 2022 Dec. Liu H, Xie Y, Wang X, Abboud MI, Ma C, Ge W, Schofield CJ. 葛微, D, 20.298. [ PubMed ]