何维课题组在《Sci Rep》 杂志发表研究论文“Hyperactivation and in situ recruitment of inflammatory Vδ2 T cells contributes to disease pathogenesis in systemic lupus erythematosus （2015）”。

      SLE患者γδ T细胞的数量表型及与病程进展的关系，揭示了γδ T细胞在SLE中的作用。中国医学科学院基础医学研究所，“医学分子生物学国家重点实验室”的何维课题组的研究揭示了炎症性Vδ2 γδ T细胞过度活化和原位募集与系统性红斑狼疮病人的疾病的发生和病程进展密切相关。

     【摘要】：In this study, we measured the proportion of peripheral Vδ2 T cells as well as the status and chemokine receptor expression profiles in SLE patients and healthy control (HC). In addition, Vδ2 T cell infiltration in the kidneys of patients with lupus nephritis was examined. The results showed that the percentage of peripheral Vδ2 T cells in new-onset SLE was decreased, and negatively correlated with the SLE Disease Activity Index score and the severity of proteinuria. These cells had a decreased apoptosis but an increased proliferation, and they showed increased accumulation in SLE kidneys. Moreover, IL-21 production and CD40L, CCR4, CCR7, CCR8, CXCR1 and CX3CR1 expression in Vδ2 T cells from SLE patients was significantly higher than from HC (p < 0.05), and these factors were downregulated in association with the repopulation of peripheral Vδ2 T cells in patients who were in remission (p < 0.05). In addition, anti-TCR Vδ2 antibodies activation significantly upregulated these chemokine receptors on Vδ2 T cells from HC, and this effect was blocked by inhibitors of PLC-γ1, MAPK/Erk, and PI3K signaling pathways. Our findings demonstrate that the distribution and function status of Vδ2 T cells from SLE patients are abnormal, and these aberrations may contribute to disease pathogenesis.

      相关结果已发表于《Sci Rep》 杂志（2015，5:14432.），其作者为何维课题组博士研究生毛昱嘉，重点室何维教授是本文的通讯作者。该研究工作得到了以下基金的支持：the National Natural Science Foundation of China (81325019, 81172859,81273312, 81302594), Beijing Municipal Natural Science Foundation (7141008, 7144208), the ResearchSpecial Fund for Public Welfare Industry of Health (20120217, 201302017), and the Capital Health Research and Development of Special Fund (2011-4001-02)。